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Reported side effects included: Nausea (most common, particularly during dose escalation) Vomiting Diarrhea Constipation Decreased appetite (this is also the mechanism, so it is both a side effect and the goal) Discontinuation due to side effects in the Phase 2 trial was around 16% in the highest dose group

Hair follicles are surrounded by skin tissue, blood vessels, and extracellular matrix

Diarrhoea and constipation represent opposite ends of the digestive spectrum, yet both are commonly reported

9), but despite this creatine kinase is not affected by SANA